Acute effects of smoking on aortic elasticity in
non-smoker healthy young subjects
Demiralp E, Kardeşoğlu E,
Cebeci B.S, Çelik T, Özmen N, Cingözbay B.Y, Işılak Z.
To determine acute effects
of smoking on aortic elasticity in nonsmoker healthy young subjects.
The study population was
composed of 25 volunteer males who were non-smokers, healthy and
moderately active (mean age: 21.6±1.5). Each subjects were asked for smoking
one cigarette within 5 minutes. Pulse rate, systolic and diastolic blood
pressure (SBP, DBP) were obtained before and after smoking. In
echocardiographic examination, aortic sytolic and diastolic diameters were
measured from M mode recordings of ascending aorta obtained at the modified
parasternal long axis views. Aortic strain (AS), aortic distensibility (AD)
and stiffness index beta (SIB) were calculated using their standart formulas
derived from aortic diameters. The parameters determined before and after
smoking were compared to each other.
We found that while EF
remained unchanged, the mean pulse rate, SBP and DBP were statistically
significant increased after smoking. It was also shown that while the mean
AS and AD were statistically significant decreased, the mean SIB was
increased.
Smoking caused an acute
increase in pulse rate, SBP and DBP associated with an acute decrease in
aortic elasticity.
Key Words:
Smoking, Aorta, Distensibility, Elasticity
go to up
Immediate effects of fluvastatin on circulating soluble endothelial protein
C and free tissue factor pathway inhibitor in acute coronary syndromes
Atalar E, Coşkun S,
Haznedaroğlu İ, Yücel N, Özer N, Sivri B, Aksöyek S, Övünç K, Özmen F.
Statins promptly lower rates
of adverse cardiovascular events in patients with acute coronary syndromes (ACS).
These therapeutic properties may be mediated by the effects of statins on
key hemostatic factors. This study examined the immediate effects of
fluvastatin on plasma free tissue factor pathway inhibitor (fTFPI) and
soluble endothelial protein C receptor (sEPCR) concentrations in patients
with unstable angina or non-ST segment elevation myocardial infarction.
We studied 57 patients
consecutively admitted to our emergency department and randomly assigned to
placebo (n=29) versus fluvastatin, 80 mg, p.o. (n=28). All patients were
treated with aspirin and metoprolol p.o., nitroglycerin i.v., and
subcutaneous enoxaparin. Venous blood was sampled as soon as possible upon
admission, before and 6 h after administration of study drug and standard
anti-ischemic therapy.
Mean sEPCR concentrations
decreased significantly in patients treated with fluvastatin (-8.1±6.7% from
baseline) and was unchanged in the placebo group (-2.3±14.4%, P=0.007 vs.
fluvastatin). Though fTFPI increased significantly after the administration
of both fluvastatin and placebo, the mean increase after fluvastatin
(450±436%) was significantly greater than after placebo (155±141%, P=0.001).
Treatment with fluvastatin
significantly modified key hemostatic factors toward an antithrombotic
effect within 6 h. These properties may, in part, explain the early salutary
effects of fluvastatin in patients with ACS.
Key Words: Fluvastatin, Acute coronary syndrome, Soluble endothelial
protein C, Tissue factor pathway inhibitor go to up
The
inverse relationship between thoracic aortic intima-media thickness and
testosterone level
Demirbağ R, Yılmaz R, Uluçay
A, Ünlü D.
It is known that
testosterone prevents coronary artery disease and lower testosterone level
is a risk factor for ischemic heart disease in men. However, there is no
report showing the relationship between testosterone level and severity of
thoracic aortic atherosclerosis. The aim of this study is investigate to
whether a relationship exists between atherosclerotic thoracic aortic intima
media thickness (TAIT) and testosterone level.
Forty-two male patients
(mean age 56±12 years) without a history of atherosclerotic cardiovascular
disease referred for TEE were included. Intima media thickness of aorta was
evaluated in each patient by using TEE. Testosterone levels were measured
using a commercial kit.
Mean testosterone values
were 507±209 ng/dl. Testosterone levels showed a negative significant
correlation with TAIT (r= -765, p<0.001). In addition, testosterone levels
showed positive correlations with albumin (r= 0.690, p=0.019) and negative
correlations with uric acid (r= -0.630, p<0.001), HsCRP (r= -0.449,
p=0.003), fibrinogen (r= -0.508, p=0.001) and white blood cells (r= -0.433,
p=0.005). On the other hand, multiple lineer regression analysis showed that
TAIT was independently associated with testosterone and uric acid (b=-0.610,
p=0.002 versus b=0.409, p=0.026 respectively)
This study indicates that
there is an independent relationship between testosterone and TAIT.
Key Words: Testosterone, Thoracic aorta intima-media thickness
transesophageal echocardiography go to up
Drug eluting stents
Bilsel T, Sayar N,
Yeşilçimen K.
Although the introduction of
coronary stents significantly improved the treatment of patients with
coronary artery disease, restenosis, due to neointimal proliferation
following stent deployment, and associated with a return of ischemic
symptoms, has remained a critical concern. Recent studies have shown that
the use of drug-eluting stents to deliver antiproliferative agents reduces
the rate of restenosis.
In this review we first
describe the structure of drug eluting stents. Secondly, we review the
current clinical drug-eluting stent studies. Finally, we discuss some major
topics about side effects and implantation techniques of drug eluting stents.
Key words:
Drug eluting stents, In-stent restenosisgo to up
Role of glycoprotein IIb/IIIa receptor
blockers in acute coronary syndromes
Yüksel Y.Ç, Uzun M.
Glycoprotein
IIB/IIIA receptor blockers are found on the cell membrane of platelets. By
binding the fibrin, they play role in platelet aggregation. The blockers of
these receptors are frequently used in the management of acute coronary
syndromes, in which the platelet agggregation plays an imporant role.
In this paper, the
literature about the use of glycoprotein IIb/IIIa receptor blockers in acute
coronary syndromes is reviewed.
Key
words:
Glycoprotein IIb/IIIa receptor, Acute coronary syndromego to up
An adult case of cor triatriatum sinister and review
of the literature
Özhan H, Ökçün B, Mutlu
H, Akdemir R, Yazıcı M, Uyan C.
Cor triatriatum sinister(CTS)
is a rare congenital malformation in which a fibromuscolar membrane
subdivides the left atrium in a postero-superior chamber and an antero-inferior
chamber. As symptoms are usually present soon after birth, diagnosis in
adulthood is extremely rare. In its classic form, the accessory chamber
receives the pulmonary veins and communication with the left atrium is
accomplished by way of one or more fenestrations in the membrane. The
malformation is usually isolated, but in about one in four patients is
associated with other congenital defects of a complex nature. We describe
an adult case of complex type CTS associated with atrial septal defect,
defined by use of transesophageal echocardiography.
Key Words: Cor
triatriatum sinister, Transesophagial echocardiographygo to up
The hypertansive patients having
non-existence of congenital left circumflex coronary artery also having
agenesis of left kidney and renal artery
Kaya M, Okyay K, Tavil Y,
Yalçın R.
Non-existence of congenital
left circumflex coronary artery is very rarely seen in anomalies of
coronary artery. The patients generally may come as mainly with chest
pain and various cardiac complains although they are asymptomatic.
This case can be seen alone and also be found with the other congenital
anomalies.
In the paper, a male
hypertansive patients, age 63 having congenital non-existence of
congenital left circumflex coronary artery and also left kidney and renal
artery agenes is this being presented.
Key words:
Circumflex coronary artery, Renal artery agenesis, Hypertension
go to up
Isolated single coronary artery anomalies arised from
right coronary sinus accompanied with diffuse atherosclerosis
Maden O, Geyik B, Öcal A,
Aras D, Şenen K, Çiçekçioğlu F, Çağlı K.
Single coronary artery, in
the absence of other congenital heart disease, is a rare coronary artery
anomaly in which only one coronary artery arises from the aorta by a single
coronary ostium supplying the entire heart. Atherosclerosis can affect this
single coronary artery complicating the clinical picture and
necessitating revascularisation as in this case. The authors present
a case of R-III C type single coronary artery anomaly in 67 years old
man affected by atherosclerosis.
Key words:
Single coronary artery, Atherosclerosis, Coronary artery anomalies
go to up
